| 产品详情 |
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| Product Name | PF-05089771 (tosylate) |
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| Description | An Nav1.7 channel blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively); selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 µM), L-type calcium, and KvLQT and hERG potassium channels (IC50s = ≥10 µM), as well as human and cynomolgus monkey TRPV1 receptors (IC50s = 10 and 20 µM); 1,000-fold selective for half-inactivated over resting Nav1.7 channels; mutation of VSD4 reduces potency by ~100-fold |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1235403-62-9 PF05089771 VSD-4 |
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| Gene, Accession, CAS # | CAS: 1430806-04-4 |
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| Catalog # | 24449-5 |
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| Order / More Info | PF-05089771 (tosylate) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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