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| Product Name | Recombinant Human Cathepsin A (CTSA) (carrier-free) |
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| Description | Cathepsin A (CTSA) is a member of S10 serine protease family and exhibits multi-enzymatic activities, such as a carboxypeptidase at an acidic condition and as a deamidase/esterase at neutral pH. CTSA is synthesized as a zymogen, a 54 kD precursor. Some evidence show that trypsin and other cathepsins (B, D, K, L) may cleave CTSA and generate mature forms of a 32kD and 20 kD disulfide-linked heterodimer in an acidic environment. CTSA forms a complex with neuraminidase (NEU1) and beta-galactosidase (GLB1) to stabilize and protect their activity against proteolysis. The deficiency in the human CTSA gene results in a lysosomal storage disorder, galactosialidosis, nephropathy, neurodegeneration, and skeletal dysplasia. In vitro and in vivo experiments have identified several CTSA substrates including peptide hormones, such as endothelin-1, bradykinin, and angiotensin I, indicating the role of CTSA in endocrine regulation. In addition, CTSA is involved in autophagy and it regulates the lysosomal-associated membrane protein type 2 (LAMP2) receptor and its degradation. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Lysosomal protective protein, Protective protein Cathepsin A (PPCA), Carboxypeptidase C, Carboxypeptidase L, Protective protein for beta-galactosidase |
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| Gene, Accession, CAS # | Gene ID: 5476 |
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| Catalog # | 757802 |
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| Order / More Info | Recombinant Human Cathepsin A (CTSA) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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