| 产品详情 |
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| Antigenic Specificity | Osteopontin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Osteopontin Polyclonal Antibody. Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D. |
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| Immunogen | n/a |
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| Other Names | SPP1, Secreted phosphoprotein 1, osteopontin, OPN, BNSP, BSPI, ETA-1 |
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| Gene, Accession # | Entrez: 20750, 25353, 6696; Uniprot: P08721, P10451, P10923 |
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| Catalog # | PA5-34579 |
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| Price | |
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| Order / More Info | Osteopontin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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