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| Product Name | PPP3CA, 1-511aa, Human, His tag, E Coli |
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| Description | MW: 60.0 kDa (534aa). Purity >85% by SDS-PAGE. PPP3CA, also known as Calcineurin A, is a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. It activates the T cells of the immune system and can be blocked by drugs. PPP3CA activates NFATc, a transcription factor by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression |
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| Size | 0.01 mg, 0.05 mg |
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| Concentration | 0.25 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [Serine/threonine-protein phosphatase 2B catalytic subunit alpha; CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B] |
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| Gene, Accession, CAS # | PPP3CA, Gene ID: 5530, Accession: NP_001124163 |
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| Catalog # | MBS203840 |
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| Order / More Info | PPP3CA, 1-511aa, Human, His tag, E Coli from MYBIOSOURCE INC. |
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| Product Specific References | Ostenfeld MS., et al. (2010) Oncogene. 29 (7):1073-84.; Rodriguez A., et al. (2009) Mol Cell. 33 (5):616-26.; |
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