| 产品详情 |
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| Antigenic Specificity | Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 0.5 mg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's antiapoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin |
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| Immunogen | A synthetic peptide derived from the C-terminus of survivin |
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| Other Names | API4|EPR-1|AAC-11|Api4|TIAP|survivin40|AP14 |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN181412 |
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| Price | |
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| Order / More Info | Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 9581817, 9859993, 9256286 |
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