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| Product Name | IL-36Ra (human) Matched Pair Detection Set |
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| Description | IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes. |
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| Size | 1 set |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | AI413231|Fil1delta|IL36RN|Il-1h3|Il1hy1|FIL1|FIL1(DELTA)|FIL1D|IL1F5|IL1HY1|IL1L1|IL1RP3|IL36RA|PSORP|Il1f5 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN2745406 |
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| Price | |
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| Order / More Info | IL-36Ra (human) Matched Pair Detection Set from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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