| 产品详情 |
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| Product Name | ONO-8711 |
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| Description | Purity >98%. Prostaglandin E2 (PGE2 ) initiates its cellular effects by activating one of four E prostanoid (EP) receptors, EP1-4 . ONO-8711 is a potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively, versus 67 and 76 nM for mouse EP3 and human thromboxane receptor, respectively, and >1,000 nM for other receptors). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer. It also suppresses pain and acid-induced HCO3- secretion in the stomach. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[(2R,3S)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid |
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| Gene, Accession, CAS # | CAS: 216158-34-8 |
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| Catalog # | LS-H9193 |
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| Order / More Info | ONO-8711 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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