| 产品详情 |
| Edit |   |
|---|
| Product Name | BH3 Interacting Domain Death Agonist (BID) protein |
|---|
| Description | BID accession number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis Synonyms: BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355 |
|---|
| Size | 2 µg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | BID|bid|si:ch211-238n5.6|fp497|xbid|DKFZp469E066|FP497|2700049M22Rik|AI875481|AU022477 |
|---|
| Gene, Accession, CAS # | Gene ID: 637 |
|---|
| Catalog # | ABIN807362 |
|---|
| Price | |
|---|
| Order / More Info | BH3 Interacting Domain Death Agonist (BID) protein from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|