| 产品详情 |
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| Antigenic Specificity | Mouse CD223 (LAG-3) |
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| Clone | C9B7W |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG1, κ |
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| Format | TotalSeq™-A oligomer conjugate |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | Proteogenomics. TotalSeq™ reagents are designed to profile protein expression at a single cell level following an optimized protocol similar to the CITE-seq workflow. |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TotalSeq™-A0378 anti-mouse CD223 (LAG-3). CD223, also known as LAG-3, is 70 kD type I transmembrane glycoprotein within the Ig superfamily. It is the gene product of lymphocyte activation gene-3 (Lag3) with structural similarity to CD4. CD223 is expressed on activated T cells and NK cells, as well as T regulatory cells. CD223, like CD4, binds MHC class II molecules, but with higher affinity than CD4. In association with the CD3 complex, CD223 has been shown as a negative regulatory molecule to inhibit TCR-mediated signaling and regulate homeostatic T cell expansion. In contrast to inhibition, CD223 has an activation function to promote immune responses by inducing MHC class II signaling in antigen presenting cells. |
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| Immunogen | Murine CD223-Ig fusion protein |
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| Other Names | LAG3, LAG-3 |
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| Gene, Accession # | Gene ID: 16768 |
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| Catalog # | 125229 |
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| Price | |
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| Order / More Info | Mouse CD223 (LAG-3) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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