| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | LCK Phospho (Tyr505) |
|---|
| Clone | A17013A |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1, κ |
|---|
| Format | phycoerythrin (PE) conjugate |
|---|
| Size | 25 tests |
|---|
| Concentration | n/a |
|---|
| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | PE anti-LCK Phospho (Tyr505). The Src family tyrosine kinase p56Lck (LCK) is a non-receptor tyrosine kinase that is primarily expressed in T cells and NK cells. It plays a critical role in T cell selection and maturation within the thymus, and also in the function of mature T cells. LCK, which is constitutively bound to cytosolic domains of CD4 and CD8 surface receptors, plays an essential role in T cell receptor (TCR) signaling. Engagement of the TCR with peptide antigen-loaded MHC complex results in the recruitment of CD4- and CD8-bound LCK to the TCR/CD3 signaling complex. LCK then transphosphorylates TCR-gamma chains and CD3 subunits, thereby activating the TCR/CD3 signaling pathway and leading to the recruitment and subsequent phosphorylation of Zap70 by LCK. LCK also plays an important role in interleukin-2 signaling that regulates the T cell proliferative response. Phosphorylation of LCK by CSK at Tyrosine 505 negatively regulates LCK, and is proposed to generate a closed, inactive conformation of the protein. |
|---|
| Immunogen | Human LCK peptide phosphorylated at Tyr 505. |
|---|
| Other Names | Leukocyte C-terminal Src kinase, Protein YT16, p56-LCK, T cell-specific protein-tyrosine kinase |
|---|
| Gene, Accession # | Gene ID: 3932 |
|---|
| Catalog # | 699703 |
|---|
| Price | |
|---|
| Order / More Info | LCK Phospho (Tyr505) Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|