| 产品详情 |
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| Antigenic Specificity | c-Cbl |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 2-5 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | c-Cbl Polyclonal Antibody. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. |
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| Immunogen | n/a |
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| Other Names | CBL; CBL2; C-CBL; RNF55; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Cas-Br-M ecotropic retroviral transforming sequence (Oncogene C |
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| Gene, Accession # | Entrez: 867; Uniprot: P22681 |
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| Catalog # | A302-338A |
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| Price | |
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| Order / More Info | c-Cbl Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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