| 产品详情 |
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| Product Name | dBET1 |
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| Description | PROTAC comprising BET antagonist (+)-JQ1 (Cat.No. 4499) conjugated to a cereblon E3 ubiquitin ligase ligand. Depletes BET bromodomains in cancer cell lines in vitro (EC50 = 430 nM in breast cancer cells) and induces apoptosis. Delays tumor growth and downregulates MYC in mice bearing human AML xenografts. Purity 98%. MW (observed): 785.27 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
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| Gene, Accession, CAS # | CAS: 1799711-21-9 |
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| Catalog # | 6327/5 |
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| Price | |
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| Order / More Info | dBET1 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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