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| Product Name | PD 180970 |
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| Description | ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Potently inhibits p210bcr/abl autophosphorylation in vitro (IC50 = 5 nM). Also potently inhibits c-Src and KIT (IC50 values are 0.8 and 50 nM, respectively). Purity 98%. MW (observed): 429.27 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one |
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| Gene, Accession, CAS # | CAS: 287204-45-9 |
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| Catalog # | 4965/10 |
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| Price | |
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| Order / More Info | PD 180970 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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