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| Product Name | PD 198306 |
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| Description | Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC50 values are > 1, > 4, > 4 and > 10 μM for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration. Purity 98%. MW (observed): 476.23 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide |
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| Gene, Accession, CAS # | CAS: 212631-61-3 |
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| Catalog # | 2605/10 |
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| Price | |
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| Order / More Info | PD 198306 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23235157 |
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| 产品资料 |
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