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| Product Name | Echinomycin |
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| Description | Highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs. Purity 98%. MW (observed): 1101.26 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether. Quinomycin A |
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| Gene, Accession, CAS # | CAS: 512-64-1 |
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| Catalog # | 5520/1 |
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| Order / More Info | Echinomycin from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 16204079 |
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| 产品资料 |
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