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| Product Name | Ro 08-2750 |
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| Description | Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation. Purity 95%. MW (observed): 270.24 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde |
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| Gene, Accession, CAS # | CAS: 37854-59-4 |
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| Catalog # | 2272/1 |
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| Price | |
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| Order / More Info | Ro 08-2750 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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