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| Product Name | Ro 5-3335 |
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| Description | Core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro. Purity 98%. MW (observed): 259.69 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one. CBFβ-Runx1 inhibitor II |
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| Gene, Accession, CAS # | CAS: 30195-30-3 |
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| Catalog # | 4694/10 |
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| Price | |
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| Order / More Info | Ro 5-3335 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 27573239 |
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