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| Antigenic Specificity | B-Cell CLL/lymphoma 2 (BCL2) (aa 61-76) |
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| Clone | 10C2 |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 is a widely studied protein that has been shown to be a potent inhibitor of programmed cell death. It has been localized to the outer mitochondrial membrane, perinuclear membrane, and endoplasmic reticulum. Bcl-2 is expressed in memory and resting, or other long-lived lymphoid cells, follicular mantle cells, medullary thymocytes, and lymphomas. Germical center cells and cortical thymocytes are negative for Bcl-2. Upregulation of Bcl-2 prevents or delays apoptosis induced by a variety of stimuli, including growth factor deprivation, -irradiation, glucocorticoids, and chemotherapeutic agents. During lymphoid development, expression of the Bcl-2 protein appears to be regulated in a stage-specific manner, and is thought to be a survival signal for positive selection. |
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| Immunogen | KLH-conjugated peptide corresponding to AA 61-76 sequence of murine Bcl-21 Ig |
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| Other Names | AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik|PPP1R50|BCL-2|bcl-2|Bcl2 |
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| Gene, Accession # | Gene ID: 12043,24224 |
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| Catalog # | ABIN135029 |
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| Price | |
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| Order / More Info | B-Cell CLL/lymphoma 2 (BCL2) (aa 61-76) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 8770886, 1950799, 9153240 |
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