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| Antigenic Specificity | B-Cell CLL/lymphoma 10 (BCL10) (aa 35-51), (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue(MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain(CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are though to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are though to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl10(35-51aa ERHFDHLRAKKILSRED), identical to the related rat and mouse sequences. |
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| Other Names | BCL10|AI132454|BCL-10|C81403|CARMEN|CIPER|CLAP|ME10|cE10|c-E10|mE10 |
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| Gene, Accession # | Gene ID: 8915,83477 |
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| Catalog # | ABIN1673013 |
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| Order / More Info | B-Cell CLL/lymphoma 10 (BCL10) (aa 35-51), (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 11163238, 9989495, 12910267 |
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