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| Product Name | Clofarabine |
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| Description | Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors. Purity 99%. MW (observed): 303.68 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
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| Gene, Accession, CAS # | CAS: 123318-82-1 |
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| Catalog # | 2600/5 |
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| Order / More Info | Clofarabine from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 22488775 |
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