| 产品详情 |
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| Product Name | LY 404187 |
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| Description | Selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo. Induces neurite growth in combination with (S)-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro. Also reduces MPTP-induced toxicity in mice. Brain penetrant. Purity 98%. MW (observed): 342.46 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide |
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| Gene, Accession, CAS # | CAS: 211311-95-4 |
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| Catalog # | 5297/50 |
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| Price | |
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| Order / More Info | LY 404187 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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