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| Product Name | PF 05212384 |
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| Description | Potent and selective dual inhibitor of PI 3-kinase/mTOR (IC50 values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over 234 other protein kinases (IC50 >10 μM). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC50 < 100 nM). Also exhibits antitumor activity in MDA-361, HCT-116, H1975 and U87MG xenograft models. Purity 98%. MW (observed): 615.73 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]urea. PKI-587, Gedatolisib |
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| Gene, Accession, CAS # | CAS: 1197160-78-3 |
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| Catalog # | 4823/10 |
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| Order / More Info | PF 05212384 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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