| 产品详情 |
| Edit |   |
|---|
| Product Name | Pladienolide B |
|---|
| Description | mRNA splicing inhibitor; decreases splicing capacity up to 75% in vitro. Directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Arrests cell cycle in G1 and G2/M phases. Displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo. Purity 95%. MW (observed): 536.7 |
|---|
| Size | 500 ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one |
|---|
| Gene, Accession, CAS # | CAS: 445493-23-2 |
|---|
| Catalog # | 6070/500U |
|---|
| Price | |
|---|
| Order / More Info | Pladienolide B from TOCRIS BIOSCIENCE
|
|---|
| Product Specific References | PubMed: 17643112, 19008883, 26700537, 27315300, 27570067 |
|---|
| 产品资料 |
|
|