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| Product Name | WYE 687 dihydrochloride |
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| Description | Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-Kα (~100-fold) and PI 3-Kγ (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Purity 98%. MW (observed): 601.53 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride |
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| Gene, Accession, CAS # | CAS: 1062161-90-3 |
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| Catalog # | 4282/10 |
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| Order / More Info | WYE 687 dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 26582390 |
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| 产品资料 |
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