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| Product Name | Human Ubiquitin E3 Ligase Complex Antibody Sampler Kit, BioAssay™ |
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| Description | Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Ubiquitin is first activated by forming a thiolester complex with the activation component E1. The activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, and then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue. Research studies suggest that activated E2 associates transiently with E3, and the dissociation is a critical step for ubiquitination. S phase kinase associated protein 1 (Skp1) is a critical scaffold protein of the Skp1/CUL1/F-box (SCF) E3 ubiquitin ligase protein complex. Various F-box proteins (e.g. beta-TrCP, Skp2) mediate an interaction with Skp1 via their defining and conserved domain of 40aa and with substrates to be ubiquitinated. RING-box protein 1 (RBX1 or ROC1) is another essential component of the SCF complex. RBX1 mediates the |
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| Size | 4x20ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 473983 |
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| Price | |
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| Order / More Info | Human Ubiquitin E3 Ligase Complex Antibody Sampler Kit, BioAssay™ from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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