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| Product Name | HVEM-Fc, Recombinant, Human (HVEM, TNFSFR14, ATAR, TR2) |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a receptor decoy resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. Biological Activity: Determined by its ability to neutralize 0.25ng/ml of hTNFbeta; induced cytotoxi |
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| Size | 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143363 |
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| Order / More Info | HVEM-Fc, Recombinant, Human (HVEM, TNFSFR14, ATAR, TR2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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