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| Product Name | HUS1, Recombinant, Human, aa2-280, His-SUMO-Tag (Checkpoint Protein HUS1) |
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| Description | Purity ~90% (SDS-PAGE). Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Source: Recombinant protein corresponding to aa2-280 from human HUS1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~47 |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: O60921 |
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| Catalog # | 373708 |
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| Order / More Info | HUS1, Recombinant, Human, aa2-280, His-SUMO-Tag (Checkpoint Protein HUS1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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