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| Product Name | EG 00229 |
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| Description | Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice. Purity 98%. MW (observed): 497.57 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine |
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| Gene, Accession, CAS # | CAS: 1018927-63-3 |
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| Catalog # | 4931/10 |
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| Price | |
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| Order / More Info | EG 00229 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 24033337 |
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| 产品资料 |
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