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| Product Name | Recombinant Human HVEM-Fc Protein |
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| Description | HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-β (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a ``receptor decoy'' resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-β. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. |
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| Size | Various Sizes |
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| Concentration | n/a |
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| Applications | Cell Culture |
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| Other Names | Immunoglobulin heavy constant gamma 1 ;Ig gamma-1 chain C region ;Ig gamma-1 chain C region EU ;Ig gamma-1 chain C region KOL ;Ig gamma-1 chain C region NIE ;IGHG1 ; HVEM, TNFSFR14, ATAR, TR2 |
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| Gene, Accession, CAS # | IGHG1, UniProt: P01857 |
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| Catalog # | PROTP01857 |
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| Order / More Info | Recombinant Human HVEM-Fc Protein from BOSTER BIO |
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| Product Specific References | n/a |
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