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| Antigenic Specificity | Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (N-Term), (pSer516) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HRX (Histone-lysine N-methyltransferase HRX) functions as histone methyltransferase. HRX methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. HRX promotes PPP1R15A-induced apoptosis. HRX interacts with SBF1 and PPP1R15A. HRX is a component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1,HCFC1 and HCFC2. Chromosomal aberrations involving MLL are a cause of acute leukemias. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. HRX belongs to the histone-lysine methyltransferase family and TRX/MLL subfamily.Synonyms: ALL1, CXXC7(CXXC-type zinc finger protein 7), HTRX, KMT2A, TRX1, MLL, Zinc finger protein HRX, Trithorax-like protein, Lysine N-methyltransferase 2A |
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| Immunogen | Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human HRX (Histone-lysine N-methyltransferase HRX) |
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| Other Names | ALL-1|CXXC7|HRX|HTRX1|MLL|MLL/GAS7|MLL1A|TET1-MLL|TRX1|WDSTS|6430520K01|All1|Cxxc7|Mll|Mll1|mKIAA4050 |
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| Gene, Accession # | Gene ID: 4297 |
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| Catalog # | ABIN966302 |
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| Order / More Info | Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (N-Term), (pSer516) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 8703835, 1423625, 8162575, 7598802 |
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