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| Product Name | MLL5 (KMT2E), Active |
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| Description | 1-548. MW: 100 kDa. Description: Recombinant human MLL5 (1-548) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3 (1). MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression (2). Isoform NKp44L acts as cellular liga |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Methyltransferase Assay |
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| Other Names | [Homo sapiens lysine methyltransferase 2E (KMT2E), transcript variant 1, mRNA; Histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase 2E; lysine methyltransferase 2E; Myeloid/lymphoid or mixed-lineage leukemia protein 5] |
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| Gene, Accession, CAS # | MLL5, Gene ID: 55904, Accession: NM_182931.2 |
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| Catalog # | MBS515549 |
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| Order / More Info | MLL5 (KMT2E), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Emerling, B.M., et al. MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene. 21 (31):4849-54, 2002. 2. Zhou, P., et al. Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem. 288 (24):17532-43, 2013. 3. Baychelier, F., et al. Identification of a cellular ligand for the natural cytotoxicity receptor NKp4 |
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