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| Product Name | MLL2 (KMT2D), Active |
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| Description | 5317-end. MW: 51 kDa. Purity >80%. Description: Recombinant human MLL2 (5317-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | 0.05 mg/ml |
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| Applications | Methyltransferase Assay |
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| Other Names | [Homo sapiens lysine methyltransferase 2D (KMT2D), mRNA; Histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase 2D; lysine methyltransferase 2D; ALL1-related protein; Myeloid/lymphoid or mixed-lineage leukemia protein 2] |
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| Gene, Accession, CAS # | MLL2, Gene ID: 8085, Accession: NM_003482.3 |
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| Catalog # | MBS515547 |
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| Order / More Info | MLL2 (KMT2D), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15 (6):334-46. 2015. 2. Huether R. et al: The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nat Commun 5: 3630. 2014. http://www.uniprot.org/uniprot/O14686 |
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