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| Antigenic Specificity | ALAS1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 1-3 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ALAS1 Polyclonal Antibody. ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme catalyzing the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthe |
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| Immunogen | n/a |
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| Other Names | ALAS-1 |
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| Gene, Accession # | Entrez: 211; Uniprot: P13196 |
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| Catalog # | PA1-41152 |
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| Price | |
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| Order / More Info | ALAS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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