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| Product Name | PKC-412 |
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| Description | MW: 570.6. Purity 98% (TLC) NMR: (Conforms). Kinase inhibitor (pan)Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM)1, PDGF-R (IC50 = 0.3 uM)1 and c-kit (IC50 = 0.1 uM)2. It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia3, gastrointestinal stromal tumors as well as several other cancers.Scientific Background: Pan-specific kinase inhibitor. Cell permeable. |
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| Size | 1 mg, 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Imatinib mesylate; 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate; STI-571] |
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| Gene, Accession, CAS # | CAS: 120685-11-2 |
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| Catalog # | MBS515011 |
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| Order / More Info | PKC-412 from MYBIOSOURCE INC. |
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| Product Specific References | E Buchdunger et al. Cancer Res. 1996 56:100 Heinrich et et al. Blood 2000 96:925 M Deininger et al. Pharmacol. Rev. 2003 55:401 |
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