| 产品详情 |
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| Antigenic Specificity | NALP10 |
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| Clone | 578502 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG2B |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | lyophilized |
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| Applications | Western Blot: 0.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NALP10 Monoclonal Antibody (578502). NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 su |
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| Immunogen | n/a |
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| Other Names | CLR11.1, NALP10, NOD8, PAN5, PYNOD, NACHT, LRR and PYD domains-containing protein 10, NACHT, leucine rich repeat and PYD containing 10, nucleotide-binding oligomerization domain protein 8, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 |
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| Gene, Accession # | Entrez: 244202, 293426, 338322; Uniprot: Q86W26, Q8CCN1 |
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| Catalog # | MA5-24260 |
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| Price | |
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| Order / More Info | NALP10 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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