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| Product Name | Recombinant Human E3 ubiquitin-protein ligase TRAIP (TRAIP) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 58.8kDa. Full Length: 1-469aa. N-terminal 6xHis-tagged. Homo sapiens (Human). E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase. Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity. The function in translesion synthesis is controversial |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | RING finger protein 206; RING-type E3 ubiquitin transferase TRAIPCurated; TRAF-interacting protein; RNF206, TRIP |
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| Gene, Accession, CAS # | TRAIP, UniProt: Q9BWF2 |
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| Catalog # | RPC23582 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase TRAIP (TRAIP) from BIOMATIK |
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| Product Specific References | n/a |
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