| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) |
|---|
| Description | Purity > 85% as determined by SDS-PAGE. MW: 58.2kDa. Full Length: 1-475aa. N-terminal 6xHis-tagged. Homo sapiens (Human). E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF (SKP2)-like complexes. A TRIM21-containing SCF (SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2 |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro (SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21; RNF81, RO52, SSA1 |
|---|
| Gene, Accession, CAS # | TRIM21, UniProt: P19474 |
|---|
| Catalog # | RPC22174 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|