| 产品详情 |
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| Antigenic Specificity | Caspase 8 |
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| Clone | 90A992 |
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| Host Species | Mouse |
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| Reactive Species | human, nonhuman primate |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.1-0.5 µg/mL, Immunohistochemistry (Paraffin): 4 µg/mL, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Caspase 8 Monoclonal Antibody (90A992). Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases play a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 w |
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| Immunogen | n/a |
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| Other Names | ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473 |
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| Gene, Accession # | Entrez: 841; Uniprot: Q14790 |
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| Catalog # | MA1-41280 |
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| Price | |
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| Order / More Info | Caspase 8 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 27060176, 27756327, 27922685 |
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