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| Antigenic Specificity | Caspase 8 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:25, Immunocytochemistry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Immunohistochemistry: 1:10-1:50, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Caspase 8 Polyclonal Antibody. Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases play a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detect |
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| Immunogen | n/a |
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| Other Names | Caspase-8; CASP-8; ICE-like apoptotic protease 5; MORT1-associated CED-3 homolog; MACH; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; Caspase-8 subunit p18; Caspase-8 subunit p10 |
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| Gene, Accession # | Entrez: 841; Uniprot: Q14790 |
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| Catalog # | PA5-13498 |
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| Price | |
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| Order / More Info | Caspase 8 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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