| 产品详情 |
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| Product Name | Osteocrin (OSTN) protein (His tag) |
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| Description | Osteocrin is a recently identified secreted protein expression of which was only detected in bone, peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 AA with a molecular mass of 11.4 kDa. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose- dependent down-regulation of osteocrin expression, suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator Synonyms: Osteocrin, Musclin, OSTN |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Other Names | DKFZp459H195|MUSCLIN|Ostc |
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| Gene, Accession, CAS # | Gene ID: 344901 |
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| Catalog # | ABIN806926 |
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| Order / More Info | Osteocrin (OSTN) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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