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| Product Name | Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1) (Active) |
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| Description | Purity > 96% as determined by SDS-PAGE and HPLC. MW: 7.0kDa. Partial of Isoform 12: 177-237aa. tag-Free. Homo sapiens (Human). Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. {ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:7902537}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Pro-NRG1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin |
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| Gene, Accession, CAS # | NRG1,GGF,HGL,HRGA,NDF,SMDF, UniProt: Q02297 |
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| Catalog # | RPC26692 |
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| Order / More Info | Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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