| 产品详情 |
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| Product Name | CC-115 |
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| Description | Purity >95%. CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC50 s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC50 = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts (mEC50 = 1 mg/kg). In a Phase I clinical trial, formulations containing CC-115 reduced lymph node sizes in almost all patients with chronic lymphocytic leukemia (CLL) that also have ataxia telangiectasia mutated (ATM) kinase deletions. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1H)-one |
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| Gene, Accession, CAS # | CAS: 1228013-15-7 |
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| Catalog # | LS-H7021 |
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| Order / More Info | CC-115 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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