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| Product Name | Recombinant Human TIR domain-containing adapter molecule 1 (TICAM1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 76.4kDa. Full Length: 1-712aa. tag-Free. Homo sapiens (Human). Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta |
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| Gene, Accession, CAS # | TICAM1, UniProt: Q8IUC6 |
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| Catalog # | RPC20814 |
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| Order / More Info | Recombinant Human TIR domain-containing adapter molecule 1 (TICAM1) from BIOMATIK |
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| Product Specific References | n/a |
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