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| Product Name | Recombinant Human TIR domain-containing adapter molecule 2 (TICAM2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 53.8kDa. Full Length: 1-235aa. N-terminal GST-tagged. Homo sapiens (Human). Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein |
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| Gene, Accession, CAS # | TICAM2, UniProt: Q86XR7 |
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| Catalog # | RPC23274 |
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| Order / More Info | Recombinant Human TIR domain-containing adapter molecule 2 (TICAM2) from BIOMATIK |
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| Product Specific References | n/a |
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