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| Product Name | Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 51.9kDa. Full Length: 1-426aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | NTEF-1; Protein GT-IIC; TEA domain family member 1 |
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| Gene, Accession, CAS # | TEAD1, UniProt: P28347 |
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| Catalog # | RPC22098 |
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| Order / More Info | Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1) from BIOMATIK |
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| Product Specific References | n/a |
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