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| Product Name | Recombinant Human Transcriptional enhancer factor TEF-3 (TEAD4), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 44.7kDa. Partial: 74-434aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | TEA domain family member 4 |
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| Gene, Accession, CAS # | TEAD4, UniProt: Q15561 |
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| Catalog # | RPC20148 |
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| Price | |
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| Order / More Info | Recombinant Human Transcriptional enhancer factor TEF-3 (TEAD4), partial from BIOMATIK |
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| Product Specific References | n/a |
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