| 产品详情 |
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| Antigenic Specificity | Roquin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 2-5 µg/mg lysate, Western Blot: 1:1,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Roquin Polyclonal Antibody. The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss. |
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| Immunogen | n/a |
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| Other Names | RC3H1, Ring finger and CCCH-type domains 1, ring finger protein 198, RNF198, roquin |
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| Gene, Accession # | Entrez: 149041; Uniprot: Q5TC82 |
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| Catalog # | A300-515A |
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| Price | |
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| Order / More Info | Roquin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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