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| Product Name | Recombinant Dog Epididymal secretory protein E1 (NPC) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 16kDa. Full Length of Mature Protein: 22-149aa. N-terminal 6xHis-tagged. Canis lupus familiaris (Dog) (Canis familiaris). Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting mbrane of late endosomes/ lysosomes to the ER and plasma mbrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Niemann Pick type C2 protein homologcE1 |
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| Gene, Accession, CAS # | NPC, UniProt: Q28895 |
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| Catalog # | RPC25380 |
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| Order / More Info | Recombinant Dog Epididymal secretory protein E1 (NPC) from BIOMATIK |
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| Product Specific References | n/a |
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