产品名称 Recombinant Human ADP-ribosylation factor 1 (ARF1) from BIOMATIK
产品货号 RPC20925
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
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Product NameRecombinant Human ADP-ribosylation factor 1 (ARF1)
DescriptionPurity > 90% as determined by SDS-PAGE. MW: 50.6kDa. Full Length of Mature Protein: 2-181aa. N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged. Homo sapiens (Human). GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Size100ug
Concentrationn/a
ApplicationsRUO
Other Namesn/a
Gene, Accession, CAS #ARF1, UniProt: P84077
Catalog #RPC20925
Price
Order / More InfoRecombinant Human ADP-ribosylation factor 1 (ARF1) from BIOMATIK
Product Specific Referencesn/a
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