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| Product Name | Recombinant Mannheimia haemolytica Leukotoxin (lktA), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 29.2kDa. Partial: 1-229aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Mannheimia haemolytica (Pasteurella haemolytica). Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca2+ and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | lktA, UniProt: P55118 |
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| Catalog # | RPC22627 |
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| Order / More Info | Recombinant Mannheimia haemolytica Leukotoxin (lktA), partial from BIOMATIK |
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| Product Specific References | n/a |
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